COVID-19疫苗接种和眼部不良事件:来自整个韩国人口的自我控制病例系列研究
Sungsoon Hwang1, Se Woong Kang2, Jaehwan Choi2
1Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine (S.H., S.W.K., J.C., K.-A.P., D.H.L., S.J.K.), Seoul, Republic of Korea; Department of Clinical Research Design and Evaluation, Samsung Advanced Institute for Health Sciences and Technology (SAIHST), Sungkyunkwan University (S.H., D.H.L., J.-Y.S., D.K., J.C.), Seoul, Republic of Korea.
American journal of ophthalmology
|August 23, 2024
概括
接种COVID-19疫苗并没有增加严重眼部事件的风险,例如视网膜动脉封闭 (RAO) 或视神经炎 (ON). 这项研究发现,接种疫苗后这些不良事件没有显著增加.
科学领域:
- 眼科医生 眼科 眼科
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 接种疫苗后的眼部不良事件是一个公共卫生问题.
- 了解COVID-19疫苗的安全概况对于公众的信任和疫苗接种至关重要.
研究的目的:
- 评估COVID-19疫苗接种后特定眼部不良事件的风险.
- 评估视网膜动脉封闭 (RAO),视网膜静脉封闭 (RVO),非传染性脑膜炎 (NIU),非传染性硬化症 (NIS),视神经炎 (ON),缺血性视神经病变 (ION) 和眼动脑神经麻 (OMCNP) 的发生率.
主要方法:
- 采用基于人口的自我控制案例系列设计.
- 分析了来自韩国的全国性索赔和疫苗接种数据 (5200万个人).
- 条件波桑回归被用来计算疫苗接种后56天内的发病率比率 (IRR).
主要成果:
- 大多数眼部事件的IRR低于1.0,表明在疫苗接种后的早期 (0-28天) 和晚期 (29-56天) 没有增加风险.
- 针对RAO的特定IRR在0.95至0.96,RVO在0.93至0.96,ON在0.91至1.04之间.
- 在接种COVID-19疫苗后,没有观察到这些眼部疾病风险的统计显著增加.
结论:
- 接种COVID-19疫苗与研究中的眼部不良事件的风险增加无关.
- 这些发现支持COVID-19疫苗对主要眼部病理的安全性.
- 这项研究有助于对COVID-19疫苗的持续药物监测.
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