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在甲素刺激小鼠中,副腹腔下垂体核的感觉输入被刺激

Shuting Ren¹, Shumin Wang¹, Siting Lv¹

¹Department of Human Anatomy, Histology and Embryology & K. K. Leung Brain Research Centre, Preclinical School of Medicine, The Fourth Military Medical University, Xi'an 710032, China; Medical School of Yan'an University, Yan'an 716000, China.

Neuroscience letters

|August 23, 2024

概括

这项研究将疼痛通路映射到副腹腔下丘脑核 (PVH). 研究结果显示,侧侧核 (LPB) 是向PVH传递炎症性疼痛信号的关键中继器.

科学领域:

神经科学是一个神经科学.
疼痛研究疼痛研究
神经内分泌学神经内分泌学

背景情况:

副腹腔下垂体核 (PVH) 对于疼痛调节至关重要.
到PVH的上升疼痛路径仍然不完全理解.

研究的目的:

为了识别特定的大脑区域,向PVH传输可感知信息.
阐明侧侧核 (LPB) 在传递炎症疼痛信号中的作用.

主要方法:

利用由甲素刺激诱导的金 (FG) 和FOS表达的逆行追踪.
采用免疫光染色来识别不同大脑区域的双标记神经元.
进行了三重染色,以分析LPB神经元中CGRP的同定位.

主要成果:

甲素注射显著增加了PVH中的FOS表达,包括催产素神经元.
对PVH的可感受输入来源于带状皮质 (Cg2),侧面隔膜核 (LS),周水管灰色 (PAG),后垂体区域 (PH) 和侧面副手臂核 (LPB).
LPB显示了对PVH的感知输入比例最高,这些神经元的一个子集表达CGRP.

结论:

这项研究在炎症性疼痛期间将 nociceptive输入档案映射到 PVH 中.
侧侧核 (LPB) 被确定为传输有害信息到PVH的关键中继器.
在LPB中表达神经元的素基因相关 (CGRP) 可能在这种疼痛途径中发挥重要作用.

关键词:

有关神经元的神经元.黄金是一种黄金.在形式上,在形式上疼痛疼痛疼痛疼痛副腹腔的下垂体细胞核.

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相关概念视频

Nociception

Nociception

Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.