持续感染SARS-CoV-2的接受者的固体器官移植:对病例报告和系列的系统审查
Andrea Lombardi1, Marta Colaneri2, Cecilia Azzarà3
1Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Infectious Diseases Unit, Milan, Italy; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.
概括
在正在进行的SARS-CoV-2感染期间进行固体器官移植 (SOT) 是可行的. 研究表明,在适合,接种疫苗并患有轻度疾病的接受者中,没有COVID-19相关的死亡.
科学领域:
- 移植医学 移植医学
- 传染性疾病 传染性疾病
- 病毒学 病毒学
背景情况:
- 在患有活跃SARS-CoV-2感染的患者中进行固体器官移植 (SOT) 的安全性仍然是一个重要的临床问题.
- 评估结果对于患者管理和手术决策至关重要.
研究的目的:
- 系统地审查和分析在正在进行的SARS-CoV-2感染的接受者中进行的SOT的结果.
- 在这个患者群体中评估故意SOT的安全性和可行性.
主要方法:
- 进行了系统的文献审查.
- 分析了29项涉及54名接受SOT同时感染SARS-CoV-2的接受者研究的数据.
主要成果:
- 腎臟移植是最常見的 (44.4%). 大多数接受者几乎没有并发症,并接种了COVID-19疫苗.
- 感染SARS-CoV-2和SOT之间的平均时间为16.1天.
- 虽然18.5%的患者需要氧气支持,13.7%的患者需要接受ICU治疗,但只有3.7%的患者因任何原因死亡,而没有与COVID-19相关的死亡.
结论:
- 在正在进行的SARS-CoV-2感染的非肺移植候选人中,可以安全地进行故意的SOT.
- 成功的结局与接受者健康,接种疫苗,并没有严重的疾病有关.
- 在这种情况下,研究结果表明COVID-19相关死亡风险较低.
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