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Updated: Jun 15, 2025

Author Spotlight: Exploring Light-Driven Chemical Reactions and Energy-Harnessing Devices in Photochemical Research
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使用PBPK-GSA方法分析驱动吸收年龄相关变化的参数影响

Donnia Robins1, Andreas Lehmann2, Katharina Krollik2

  • 1Global Drug Product Development, Global CMC Development, Merck KGaA, Frankfurter Straße 250, Darmstadt, Germany; Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Zografou, Greece.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
|August 23, 2024
PubMed
概括

以生理学为基础的药理动力学 (PBPK) 模型得到了全球灵敏度分析的增强,以评估与年龄相关的吸收变化. 这种方法改善了对老年人群药物安全性的风险分析.

关键词:
全球敏感性分析莫里斯 莫里斯 莫里斯 莫里斯老年人,年长的人.通过PK-Sim®,可以实现PK-Sim®.基于生理学的药物动力学建模.风险查 风险查

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