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威利斯圆的配置和内动脉多利科克塔西亚之间的相关性,以及遗传贡献

Lu Feng¹, Xin-Zhuang Yang², Ding-Ding Zhang²

¹Department of Neurology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Science, Beijing, China.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

|August 23, 2024

概括

威利斯圆圈 (COW) 的变化与一般人群中较大的内动脉直径有关. 遗传因素可能会影响COW变异和内动脉扩张.

科学领域:

神经成像是一种神经成像.
遗传学是一个遗传学.
血管生物学血管生物学

背景情况:

内动脉多利赫克塔西亚 (IADE) 涉及大脑动脉的异常扩张,延长和扭曲.
威利斯圆 (Circle of Willis,简称COW) 是大脑底部的一个关键性动脉动脉系统.
了解影响IADE的因素对于管理脑血管风险至关重要.

研究的目的:

在一般人群中调查威利斯圆 (Circle of Willis,COW) 变异与内动脉多利切除症 (intracranial arterial dolichoectasia,IADE) 之间的关联.
估计COW变异与IADE之间的遗传相关性.

主要方法:

981个人的基于人口的队列.
脑磁共振血管造影用于COW变体评估和动脉直径测量.
全基因组复杂特征分析 (GCTA) 用于遗传性和遗传相关性估计.

主要成果:

IADE的流行率为6.2%.
低塑性/缺席的A1段与改变的ipsilateral和contralateral内动脉 (ICA) 直径相关.
胎儿类型的后脑动脉 (FTP) 与ICA和基底动脉 (BA) 直径有显著的关联.
FTP证明了与ICA扩张的积极遗传相关性,与BA扩张的负相关性.

结论:

威利斯圆 (COW) 变异与内动脉直径的增加有关.
遗传因素可能有助于内动脉扩张和COW变异的发展.

关键词:

动脉直径为动脉的直径.威利斯的圆圈威利斯的圆圈杜利科埃克塔西亚 (Dolichoectasia) 是一种多利科埃克塔西亚.遗传相关性遗传相关性

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