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曼尼托尔对冠状动脉旁路移植患者手术后的作用:一项随机对照试验

Masumeh Hemmati Maslakpak¹, Sohrab Negargar², Ali Farbod³

¹Maternal and Childhood Obesity Research Center, Nursing and Midwifery School, Urmia University of Medical Sciences, Urmia, Iran (the Islamic Republic of).

|August 23, 2024

概括

将曼尼托尔添加到心肺旁路主要溶液中,显著减少了心脏手术患者的术后妄想. 这种干预提供了一个有前途的策略,以改善冠状动脉旁路手术后的患者结果.

科学领域:

心脏病学心脏病学
麻醉学麻醉学
神经外科神经外科

背景情况:

手术后痴呆症 (POD) 是心肺绕道 (CPB) 心脏手术后的一个常见并发症.
POD增加了副作用,住院,死亡率和医疗保健成本.
预防POD对于改善患者康复和减少医疗负担至关重要.

研究的目的:

评估CPB主要溶液中曼尼托尔在接受冠状动脉旁路手术的患者中预防POD的疗效.
评估曼尼托尔对POD发病率的影响.
调查二次结果,包括通风持续时间,ICU停留时间和死亡率.

主要方法:

一个单中心,双盲,随机对照试验从2022年12月到2023年5月进行.
包括18至70岁的接受选择性冠状动脉旁路手术的患者.
干预组 (n=45) 接受了CPB原溶液中的200毫升曼尼托尔,而对照组 (n=45) 接受了林格的乳酸盐.

主要成果:

与对照组 (42.2%) 相比,曼尼托尔组 (22.25%) 的POD发病率明显较低 (p=0.035).
在人口特征,CPB时间,大动脉十字时间,机械通风持续时间,ICU停留时间,死亡率或返回手术室方面没有发现显著差异.
曼尼托尔的使用没有影响关键的外科或外科周围的参数.

结论:

将曼尼托尔添加到CPB主要溶液中是一种有效的策略,可以减少心脏手术后POD的发生率.
这种干预显示出改善患者结果和减少与心脏手术相关的并发症的潜力.
进一步的研究可能会探索最佳的曼尼托尔剂量及其长期影响.

关键词:

心脏外科手术程序心脏外科手术程序冠状动脉绕道 (bypass) 是一种冠状动脉绕道.人工心脏,人工的心脏

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