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Updated: Jun 15, 2025

Hybrid Cell Analysis System to Assess Structural and Contractile Changes of Human iPSC-Derived Cardiomyocytes for Preclinical Cardiac Risk Evaluation
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无机硫化物可以预防由osimertinib诱导的人类iPS细胞衍生的心肌细胞中的线粒体功能障碍

Moe Kondo1, Yuya Nakamura2, Yuri Kato2

  • 1Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan; Department of Physiology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, 812-8582, Japan.

Journal of pharmacological sciences
|August 23, 2024
PubMed
概括

像奥西默提尼布这样的癌症药物可以伤害心脏. 这项研究发现无机硫供体,特别是硫化 (Na2S),可以通过维护线粒体健康来保护对 osimertinib 诱导的心脏毒性.

关键词:
心脏衰竭是因为心脏衰竭.线粒体中的线粒体.瘤心脏病学 瘤心脏病学奥西默蒂尼布 (Osimertinib) 是一种药物.这是一种超硫化物.

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