肠道淋巴生物学,药物输送和治疗方法:当前状态和未来方向
Sanjeevini Babu Reddiar1, Yining Xie1, Mohammad Abdallah1
1Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia (S.B.R., Y.X., M.A., S.H., L.H., O.M.F., G.G., A.A., Z.L., M.A.F., I.K.S., C.J.H.P., E.C., N.L.T.); China Pharmaceutical University, Nanjing, China (S.H., L.H.); Applied Surgery and Metabolism Laboratory, School of Biological Sciences (A.R.J.P.) and Surgical and Translational Research Centre, Department of Surgery, Faculty of Medical and Health Sciences (A.R.J.P., J.A.W.), University of Auckland, Auckland, New Zealand; and Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia (N.L.T.).
肠道淋巴系统现在被理解为药物输送的活跃途径. 新的策略利用这个系统来增强治疗效益和药物吸收.
科学领域:
- 胃肠病学和药理学 胃肠病学和药理学
- 淋巴系统生理学 淋巴系统生理学
- 药物输送系统 药物输送系统
背景情况:
- 从历史上看,肠道淋巴管被认为是被动的导管.
- 最近的研究揭示了它们在生物过程中的活跃,动态作用.
- 这种范式的转变影响了药物和疫苗的交付策略.
研究的目的:
- 审查胃肠道淋巴系统的解剖学和生理学.
- 专注于与肠道淋巴药物输送相关的方面.
- 总结目前和未来通过这种途径输送药物的战略.
主要方法:
- 淋巴系统研究的综合文献综述.
- 对影响淋巴运输的药物物理化学性质的分析.
- 评估新型的输送系统 (纳米技术,脂质前期药物).
主要成果:
- 已证明肠道淋巴细胞的活性和特异性作用.
- 突出了利用淋巴管道的先进药物输送策略.
- 展示了淋巴输送的显著药理动力学和治疗优势.
结论:
- 肠道淋巴管为药物和生物物质的输送提供了一个有前途的途径.
- 先进的策略正在改善药物吸收和治疗结果.
- 进一步开发对于这些输送系统的临床应用至关重要.
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