长期COVID-19中的微生物组和自身免疫的交集:当前的见解和未来的方向
Altijana Hromić-Jahjefendić1, Lejla Mahmutović1, Abas Sezer1
1Department of Genetics and Bioengineering, Faculty of Engineering and Natural Sciences, International University of Sarajevo, Hrasnicka cesta 15, Sarajevo 71000, Bosnia and Herzegovina.
Cytokine & growth factor reviews
|August 23, 2024
概括
长期的COVID-19可能会引发自身免疫反应,因为免疫系统的调节失调. 针对肠道微生物组的干预措施,如益生菌和益生菌,在管理长期COVID自身免疫力和改善患者康复方面表现有前途.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 传染性疾病 传染性疾病
背景情况:
- 长期COVID-19呈现出各种症状,包括疲劳和认知问题,并且越来越多地与自身免疫性疾病有关.
- 长期COVID的自身免疫包括免疫过度激活,中性粒细胞外细胞陷 (NET) 形成和分子模仿.
- 关键特征包括高度警的免疫系统,改变的免疫细胞,来自中性粒细胞的自身抗原和高水平的自身抗体.
研究的目的:
- 探索肠道微生物组和长期COVID-19中的自身免疫反应之间的联系.
- 调查微生物组变化如何影响长期COVID相关自身免疫的严重程度和进展.
- 确定针对长期COVID恢复的微生物组的潜在治疗策略.
主要方法:
- 关于长期COVID,自身免疫和微生物组的当前科学文献的审查.
- 分析在后COVID条件下将微生物失调与免疫失调联系在一起的拟议机制.
- 对微生物组调节干预措施的新兴证据的审查.
主要成果:
- 肠道微生物组在调节免疫反应和整体健康方面发挥着至关重要的作用.
- 微生物组的组成可以影响长期COVID自身免疫的过程,影响疾病的严重程度和恢复.
- 新兴研究表明,针对微生物组的疗法可能会减轻自身免疫反应.
结论:
- 微生物组在长期COVID自身免疫中的作用需要进一步调查.
- 益生菌,益生菌和饮食修改是管理长期COVID相关自身免疫力的潜在干预措施.
- 专注于微生物组的量身定制治疗计划可以改善长期COVID幸存者的结果.
相关概念视频
01:29Autoimmune Disorders
398
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
398
01:17Chronic Bowel Disorders: Introduction
420
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
420
01:17Irritable Bowel Syndrome I: Introduction
263
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
263