不同口水对呼吸机相关结果和重症监护病人的死亡率的影响:一个网络的元分析
Qianqian He1, Zengjin Peng2, Caiyun He1
1Medical College, Hunan Normal University, No. 371 Tongzipo Road, Yuelu District, Changsha, Hunan, China.
概括
盐水口水显著降低了呼吸器患者的重症监护室 (ICU) 死亡率,而氧化剂显示出降低呼吸器相关肺炎 (VAP) 的潜力. 抗菌口水可能会带来风险.
科学领域:
- 关键护理医学 关键护理医学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 呼吸机相关肺炎 (VAP) 是重症监护室 (ICU) 中的一个关键并发症.
- 口腔卫生对于预防VAP至关重要,但最佳的口水疗效尚不清楚.
- 这项研究评估了机械通风ICU患者常用的口水.
研究的目的:
- 系统地比较各种口水溶液的有效性和安全性,用于机械通风ICU患者的口腔护理.
- 确定有效降低VAP发生率和ICU死亡率的口水.
- 为ICU中最佳口腔护理方案提供证据.
主要方法:
- 进行了随机对照试验 (RCT) 的网络元分析 (NMA).
- 搜索的数据库:PubMed,科学网,Embase,科克兰图书馆.
- 包括的研究比较了盐水,素,二碳酸,氧化剂,草本提取物和波维-.
主要成果:
- 分析了14个RCT,其中有1644名参与者.
- 氧化剂趋向于减少VAP发生率 (RR:0.24;95%CI:0.05-1.10).
- 与没有口水相比,盐水显著降低了ICU死亡率 (RR:0.18;95%CI:0.04-0.88).
结论:
- 抗微生物口水,特别是赫西丁,可能会给ICU患者带来风险.
- 氧化溶液似乎相对安全,盐水显示有望降低死亡率.
- 需要进一步的大规模,高质量的RCT来证实研究结果,并指导基于证据的口腔护理.
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