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Updated: Jun 15, 2025

A Chromatin Immunoprecipitation Assay to Identify Novel NFAT2 Target Genes in Chronic Lymphocytic Leukemia
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MEF2B C端突变增强了转录活性和稳定性,推动了B细胞淋巴发育

Chuanjiang Yu1, Qiong Shen1, Antony B Holmes1

  • 1Institute for Cancer Genetics, Columbia University, New York, NY, USA.

Nature communications
|August 23, 2024
PubMed
概括

肌细胞增强因子2B (MEF2B) 转录因子的突变破坏其C尾酸化,增强其活性和稳定性. 这导致生殖中心B细胞淋巴瘤的发展.

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