在老年胃癌患者肺功能障碍的预后影响
Kazuya Takabatake1, Shinichi Sakuramoto2, Ryota Kobayashi2
1Department of Gastrointestinal Surgery, Saitama Medical University International Medical Center, 1397-1, Yamane, Hidaka-Shi, Saitama, 350-1298, Japan. batake@saitama-med.ac.jp.
Scientific reports
|August 23, 2024
概括
限制性肺功能障碍,以低生命能力为标志,增加了肺炎的风险,并对老年胃癌患者的预后产生负面影响. 阻塞性功能障碍没有显著的影响.
科学领域:
- 老年医学 老年医学
- 肺部病理学 肺部病理学
- 手术瘤学手术瘤学
背景情况:
- 肺功能障碍是接受重大手术的老年患者的一个担忧.
- 在老年人中,胃癌手术需要仔细评估并发症.
- 具体的肺功能障碍类型对结果的影响需要澄清.
研究的目的:
- 评估限制性和阻塞性肺功能障碍对老年胃癌患者手术后结果的影响.
- 确定肺功能参数作为胃切除术后不良结果的风险因素.
主要方法:
- 对352名75岁以上的胃癌患者进行了回顾性分析,这些患者接受了治疗性胃切除术.
- 术前螺旋测量用于定义限制性 (%VC < 80%) 和阻塞性 (FEV1.0% < 70%) 肺功能障碍.
- 分析的结果包括术后肺炎和长期预后,对腹腔镜手术和开放手术进行亚组分析.
主要成果:
- 限制性肺功能障碍 (%VC < 80%) 与术后肺炎的发病率较高有关 (p=0.018).
- 阻塞性肺功能障碍 (FEV1.0%<70%) 与肺炎没有显著联系 (p=0.677).
- 降低%VC是肺炎的重要风险因素,但这在腹腔镜胃切除术患者中没有观察到. 限制性功能障碍对长期预后产生了负面影响.
结论:
- 限制性肺功能障碍是术后肺炎的重要危险因素,也是老年胃癌患者的负面预后因素.
- 阻塞性肺功能障碍似乎不会显著影响手术后肺炎风险或该人口的长期预后.
- 腹腔镜手术可以减轻限制性功能障碍和术后肺炎之间的关联.
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