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根据角膜拓图的基础,对严重角膜的进展进行了纵向评估

XiaoDi Yang¹, YiRan Wang², YuYing Liu²

¹The First Affiliated Hospital of Zhengzhou University, Jianshe Road, Zhengzhou, 450000, China. 446494313@qq.com.

Scientific reports

|August 23, 2024

概括

严重角膜炎 (KC) 患者佩戴刚性气透性隐形眼镜 (RGPCL) 在2-3年内减少了前角膜曲率. 角膜厚度保持稳定,在这项长期研究中观察到的疾病进展最小.

科学领域:

眼科医生眼科眼科
角膜疾病角膜疾病
生物医学工程生物医学工程

背景情况:

角膜 (KC) 是一种渐进的角膜脱光症,导致视力受损.
严重的KC病例需要长期管理策略来监测疾病进展.
刚性气体透性隐形眼镜 (RGPCL) 是一种常见的治疗方法,用于纠正KC患者的视力.

研究的目的:

为了评估重度角 (KC) 患者的长期疾病进展.
评估经过延长RGPCL磨损的严重KC患者角膜拓学参数的变化.
在这个患者队列中确定影响疾病进展的因素.

主要方法:

从125名患有严重的KC患者的临床记录进行了回顾性分析,其中包括28名患者 (31只眼睛).
评价角膜地形参数:最薄角膜厚度 (TCT),最大角膜测量 (Kmax),前后角膜半径 (aKM,pKM) 和KC查指数.
长期随访 (中位数为25个月) 患者佩戴刚性气透性隐形眼镜 (RGPCL).

主要成果:

观察到前角膜曲率 (aKM,Kmax) 和KC查指数显著降低 (P <0.05).
在RGP校正的视敏度,角膜厚度 (TCT) 或后角膜参数 (pKM) 中没有发现显著变化.
较高的基线aKM和Kmax值与这些参数的较大减少相关;16%的患者表现出疾病进展.

结论:

患有严重的KC患者佩戴RGPCL两三年,显示前角膜曲减少,角膜厚度没有显著变化.
在严重的角膜癌中,RGPCL的磨损可能会稳定角膜厚度,尽管前曲率的变化仍然存在.
对于严重的KC患者来说,长期监测至关重要,因为尽管使用RGPCL,但部分患者可能仍然会出现疾病进展.

关键词:

克拉托科努斯 (Keratoconus) 是一种类型的角质球.追溯研究是一项回顾性研究.刚性气体透角膜隐形眼镜的隐形眼镜.

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