甲状腺激素敏感性和糖尿病外围神经病变之间的相关性,在2型糖尿病患者中
Meixin Sun1, Lu Yu2, Xue Zhao1
1Department of Endocrinology and Metabolism, The First Hospital of Jilin University, 71 Xinmin Street, Chaoyang District, Changchun, 130021, China.
Scientific reports
|August 23, 2024
概括
降低甲状腺激素 (TH) 敏感性与2型糖尿病患者糖尿病外围神经病变 (DPN) 的风险较低有关. 这项研究探讨了TH敏感度.
科学领域:
- 内分泌学和新陈代谢学
- 神经学 神经学
- 糖尿病学 糖尿病学
背景情况:
- 甲状腺激素 (TH) 水平与糖尿病外围神经病变 (DPN) 风险有关,在患有2型糖尿病 (T2DM) 的甲状腺患者中.
- 甲状腺激素敏感性和DPN之间的关系尚不清楚,需要进一步调查.
研究的目的:
- 调查DPN和甲状腺激素敏感性之间的相关性,在T2DM的euthyroid患者.
- 评估与DPN发展相关的外围和中央TH敏感性.
主要方法:
- 追溯地招募708名患有T2DM的平甲状腺成年人.
- 使用FT3/FT4比率估计的外围TH灵敏度.
- 通过TT4RI,TSHI,TFQI和PTFQI指数评估的中央TH敏感性;通过临床评估和神经传导速度测试诊断的DPN.
- 使用后勤回归分析来检查DPN和TH灵敏度之间的关系.
主要成果:
- 高FT3/FT4比率与增加DPN风险显著相关 (OR=1.36).
- 增加的中央TH敏感性 (更高的TT4RI,TSHI,TFQI,PTFQI) 与DPN风险降低有关.
- 对于TT4RI,TSHI,TFQI和PTFQI中的每个SD增加,DPN的几率显著下降 (ORs从0.69到0.80不等).
结论:
- 降低中部和外围甲状腺激素敏感性与乙状腺T2DM患者患糖尿病外围神经病变的风险降低有关.
- 甲状腺激素敏感性可能成为预测该人口中DPN风险的潜在生物标志物.
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