维生素D水平与白内障之间的关联:系统性审查和元分析
Zhenzhen Jue1, Ziming Xu1, Vincent L Yuen1
1Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, 147K Argyle Street, Kowloon, Hong Kong SAR, China.
概括
血清维生素D水平较低与白内障发病率较高有关. 这种关联在女性和特定白内障类型 (如核白内障和后子白内障) 中更为明显.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 营养科学 营养科学
背景情况:
- 血清维生素D水平与白内障形成之间的关系尚未完全理解.
- 之前的研究对这种关联产生了相互矛盾的结果.
研究的目的:
- 进行元分析,评估血清维生素D水平与白内障发生率之间的关联.
- 根据性别和白内障亚型,探索这种关联中的潜在差异.
主要方法:
- 在PubMed,Web of Science和EMBASE数据库中进行了系统的文献搜索,截至2023年8月30日.
- 四项研究,包括10,928名白内障患者和10,117名对照受试者,符合分析的纳入标准.
主要成果:
- 在较低的血清维生素D水平和较高的白内障发病率 (P=0.047) 之间发现了统计学上显著的关联.
- 亚组分析显示,男性 (P=0.01) 和女性 (P<0.01) 都存在显著的关联,女性的关联更强.
- 核性白内障 (P<0.01) 和后部亚囊性白内障 (P=0.02) 也发现了显著的关联,但皮质白内障 (P=0.14) 没有.
结论:
- 这一元分析表明,血清维生素D水平与白内障之间存在潜在的关联.
- 这种联系在女性和特定白内障亚型,即核白内障和后子白内障中显得更为显著.
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