在接受化疗的淋巴瘤患者中发生的Bifidobacterium血流感染:一个案例研究和益生菌使用的影响
Osamu Imataki1, Makiko Uemura1
1Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Miki, Kagawa, Japan.
The American journal of case reports
|August 24, 2024
概括
发酵细菌,不仅仅是益生菌,可以导致免疫功能低下的癌症患者的血液感染. 早期使用抗生素治疗导致完全缓解,强调需要仔细监测.
科学领域:
- 微生物学 微生物学
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 乳酸产生发酵细菌,包括Bifidobacterium spp.,通常被认为具有较低的致病性. 含有这些细菌的益生菌用于胃肠道疾病和免疫受损患者,包括癌症患者,由于对肠道微生物群的积极影响. 然而,罕见的血流感染与益生菌相关的病例已报告.
- 在癌症患者中完全禁止益生菌的使用可能会否定其益处,需要考虑潜在风险的平衡方法.
研究的目的:
- 在接受化疗的癌症患者中报告Bifidobacterium breve血流感染病例.
- 讨论潜在的感染源及其管理.
- 突出对免疫功能低下个体使用益生菌的更广泛影响.
主要方法:
- 一个75岁的日本妇女患有恶性淋巴瘤,接受R-CHOP化疗的病例报告.
- 监测发烧性中性质和鉴定Bifidobacterium breve血流感染的情况.
- 评估患者的饮食习惯,包括酸奶消费.
主要成果:
- 患者在化疗期间出现了Bifidobacterium breve血流感染.
- 这种感染与她经常食用含有牛奶的酸奶没有直接联系,牛奶中含有牛奶杆菌bulgaricus和热杆菌thermophilus.
- 患者在8天的时间里成功地接受了美罗胺的治疗,并实现了血液感染的完全缓解.
结论:
- 发酵细菌,而不仅仅是益生菌菌株,在接受化疗的癌症患者中可能是血液感染的来源.
- 益生菌可能仍然有益于缓解免疫功能低下患者的食道症状.
- 对非益生菌细菌感染的警对于免疫功能受损的癌症患者至关重要.
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