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Sonja Steen¹, Dominik Horn², Christa Flechtenmacher^3,4

¹Department of Oral and Cranio-Maxillofacial Surgery, University of Heidelberg, Heidelberg, Germany.

|August 24, 2024

概括

SOX2和SOX9转录因子与癌症进展有关. 它们在口腔状细胞癌 (OSCC) 中的表达模式影响患者的存活率,SOX2低SOX9高表明预后较差.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
遗传学遗传学是一个

背景情况:

SOX2和SOX9是与癌症干系相关的转录因子.
这些因素影响瘤的生长,转移和治疗耐药性.

研究的目的:

评估在口腔状细胞癌 (OSCC) 中的SOX2和SOX9表达.
评估SOX2和SOX9在OSCC患者的预后意义.

主要方法:

在一大群OSCC患者中分析SOX2和SOX9表达.
包括原发性瘤,复发性瘤和淋巴结转移.
半自动数字病理学蛋白质表达和生存分析的预后意义.

主要成果:

从初级OSCC到淋巴结转移观察到SOX9的显著下调.
SOX9表达和SOX2低SOX9高子组与较差的整体存活率相关.
SOX2低SOX9高表达模式被确定为整体存活的独立预后因素.

结论:

SOX2和SOX9在OSCC患者的治疗结果中起着重要作用.
这些发现强调了在OSCC中调查SOX相关的基因表达机制的临床相关性.

关键词:

这是OSCCCC的OSCC.这就是SOX2的含量.这就是SOX9的SOX9.口腔癌是指口腔癌的发生.幸存率幸存率生存率

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Pleiotropy

Pleiotropy

Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...