一个"R-spondin代码"用于多式联网信号的ON-OFF状态
Christof Niehrs1,2, Carina Seidl1, Hyeyoon Lee1
1Division of Molecular Embryology, DKFZ-ZMBH Alliance, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.
概括
R-spondins (RSPO) 是调节Wnt信号传递的干细胞生长因子. 新的研究确定了额外的RSPO目标,并提出了用于组合信号控制在发育和疾病中的"R-spondin代码".
科学领域:
- 细胞生物学 细胞生物学
- 分子生物学分子生物学
- 发展生物学 发展生物学
背景情况:
- R-spondins (RSPO) 是分泌的蛋白质,作为干细胞生长因子.
- 众所周知,RSPO是Wnt信号的共同激活者,可以放大其效果.
- RSPO2和RSPO3也与BMP和FGF受体结合,降低它们各自的信号通路的调节.
研究的目的:
- 为了确定R-spondins的新细胞表面点.
- 阐明RSPO调节多种信号通路的机制.
- 提出一种新的框架,即"R-spondin代码",用于理解组合信号.
主要方法:
- 蛋白相互作用数据库的数据挖掘.
- 细胞表面结合测试用于验证RSPO目标.
- 分析R-脊髓蛋白模块域及其功能.
主要成果:
- 确定了SMO,PTC1,2,LGI1,ROBO4和PTPR (F/S) 作为新的RSPO候选目标.
- 证实RSPO的功能是"内细胞体",将跨膜蛋白与ZNRF3/RNF43 E3连接酶连接起来以进行内部化.
- 证明RSPO-TSP1领域的独特动机调解了目标交互和内部化.
结论:
- RSPOs 作为细胞表面蛋白质的天然蛋白质向仿真体.
- "R-spondin代码"框架解释了RSPO如何传递组合信号状态.
- 该规范为发展和疾病中信号通路的协调调节提供了新的视角.
关键词:
在BMP中,BMP是BMP.联邦政府财政基金.刺是一种刺.在R-spondin的研究中,他们不想做.轴突指导指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导轴突指导导轴突指导导轴突指导轴突指导轴指导轴指导轴酸酶是一种酸酶.接收器内部化 接收器内部化更多相关视频
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