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基尼胺调节GSK3β以抑制Th17分化并减轻内动脉瘤中的内皮损伤

Qian Zhang1, Lu-Feng Shi1, Run-Dong Chen2

  • 1Department of Neurosurgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Phytotherapy research : PTR
|August 24, 2024
PubMed
概括

基尼胺 (Gen) 通过抑制通过GSK3β的Th17细胞分化,有效地治疗内动脉瘤 (IA). 这种机制保护内皮细胞,减少脑血管疾病的严重程度.

关键词:
CD4 T 淋巴细胞 CD4 淋巴细胞基因化物是一种基因化物.威利斯的圆圈是一个圆圈.头骨内动脉瘤是什么意思紧密的连接蛋白质紧密的连接蛋白质.血管内皮细胞是血管内皮细胞.

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The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors are of three kinds RI, RII, and RIII. The RI...