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高剂量的维生素B6可以减少感官过度反应
Rebekah O Cracknell1, Teresa Tavassoli1, David T Field1
1School of Psychology and Clinical Language Sciences, The University of Reading, Reading, Berkshire, UK.
Journal of psychopharmacology (Oxford, England)
|August 24, 2024
概括
高剂量的维生素B6补充剂有效地减少了成年人的感官过度反应 (SOR) 和姿势障碍. 这表明维生素B6可能是一个可行的干预对于经历感官处理挑战的个人.
科学领域:
- 神经科学是一个神经科学.
- 人体生理学 人体生理学
- 营养科学 营养科学
背景情况:
- 感官反应性差异影响5-15%的人口,通常表现为感官过度反应 (SOR).
- SOR涉及经历强烈的感官刺激,影响日常功能.
- SOR的潜在原因是神经刺激和抑制之间的不平衡,抑制作用减弱.
研究的目的:
- 为了确定高剂量维生素B6补充是否可以减少感官过度反应 (SOR) 和其他感官反应方面的问题.
- 调查维生素B6在调节涉及感官处理的神经通路中的有效性.
主要方法:
- 300名成年人在基线和补充1个月后完成了感官处理3维量表 (SP-3D).
- 参与者被随机分配,接受100毫克维生素B6,1000微克维生素B12或安慰剂.
- 分析的重点是具有高基线SOR得分 (87百分比以上) 的个体.
主要成果:
- 与安慰剂和维生素-B12相比,维生素-B6在具有基线SOR的个体中选择性地降低了SOR.
- 维生素B6还可以选择性地降低那些对这个子表的高基线得分的人的姿势障碍.
- 在剩余的四个SP-3D子尺度上没有观察到显著的影响.
结论:
- 高剂量的维生素B6在减少感官过度反应和姿势障碍方面显示出有前途.
- 进一步的临床试验和机制研究在SOR患者群体中是有必要的,例如自闭症和ADHD.
- 维生素B6作为GABA合成中的辅酶的作用表明其作用的潜在神经生物学机制.
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