在患有精神疾病的儿童和青少年患者中,长效注射抗精神病药物启动
Christina Sun1, Andreea Temelie1, Hannah Goulding1
1UPMC Western Psychiatric Hospital, Pittsburgh, Pennsylvania, USA.
Journal of child and adolescent psychopharmacology
|August 24, 2024
概括
这项研究对儿童和青少年精神病医院住院患者的长效注射抗精神病药物 (LAIA) 进行了研究. 调查结果显示,剂量与成人指导方针的差异很大,并显示出显著的再入院率,这凸显了进一步研究的必要性.
科学领域:
- 儿童和青少年精神病学
- 药理学 药理学是指药理学的学科.
- 临床研究 临床研究
背景情况:
- 长效注射抗精神病药物 (LAIA) 并未获得FDA批准用于儿科,但被处方为非标签.
- 关于LAIA在儿童和青少年群体中的启动和剂量的数据有限.
研究的目的:
- 描述儿童精神病医院住院患者的LAIAs的启动和维持剂量策略.
- 分析患者人口统计和与LAIA使用相关的诊断. 在这个年龄组.
主要方法:
- 在住院期间开始服用LAIA的18岁以下患者的回顾性图表审查.
- 数据收集包括人口统计,诊断,LAIA药物,剂量方案,停留时间和再接收率.
- 描述性统计数据用于分析.
主要成果:
- 在6402名儿科患者中,有45名 (0.7%) 开始接受LAIA,平均年龄为15.6岁.
- 帕利佩里棕酸和阿里皮普拉单酸是最常见的LAIA,用于诊断包括精神病和双相情感障碍.
- 17名患者 (37.8%) 接受了不同于成人包装插件的剂量,31.1%在6个月内重新入院.
结论:
- 这是第一个详细介绍儿科住院患者LAIA剂量策略的研究.
- 剂量往往偏离成人推,再入院率显著.
- 需要进一步的研究来评估LAIA的疗效和对儿童和青少年临床结果的影响.
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