分析美国销售的用于狗的美素补充剂
Alyssa R Berman1, Adam J Birkenheuer1, Emily L Sorah2
1Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA.
Journal of veterinary pharmacology and therapeutics
|August 24, 2024
概括
对于患有Babesia gibsoni的狗,未经批准的素补充剂显示出强度和纯度的显著变化. 在临床使用之前,由于活性化合物的质量不一致和潜在缺乏活性化合物,测试至关重要.
科学领域:
- 兽医药理学 兽医药理学
- 寄生虫学的寄生虫学
- 分析化学 分析化学
背景情况:
- 口服的阿尔特米西宁显示出对狗的巴贝西亚 gibsoni 感染的抗寄生虫潜力.
- 素补充剂是不受监管的植物产品,缺乏安全性和有效性评估.
研究的目的:
- 评估来自四个不同供应商的阿尔特米西宁囊的强度和可变性.
- 在潜在的临床研究使用之前,确定这些补充剂是否符合既定的质量标准.
主要方法:
- 使用经过验证的高性能液态染色学 (HPLC) 方法进行定量分析.
- 评估了四种商业上可用的甲美西宁囊产品.
主要成果:
- 观察到阿尔特米西宁囊强度在产品内和产品之间有显著的变化.
- 没有任何测试的产品符合美国药典 (USP) 和国际协调委员会 (ICH) 的接受标准.
- 一种产品不含可检测的美素;三种产品超过标签强度.
结论:
- 未经批准的美素补充剂表现出不可靠的强度和质量.
- 在推它们用于治疗犬类Babesia gibsoni之前,对不受管制的补充剂进行严格的测试至关重要.
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