在查系统性自身免疫性类风湿性疾病的CA 15 - 3相关的间歇性肺病:一个单一中心的横截面研究
Kristina Frketic Marovic1,2, Zeljka Kardum3,4, Ines Sahinovic4,5
1Department of Internal Medicine, General Hospital Zadar, Boze Pericica 5, Zadar, 23000, Croatia. kmarovic7@gmail.com.
Rheumatology international
|August 24, 2024
概括
碳水化合物抗原15-3 (CA 15-3) 是一种有前途的查工具,用于在患有系统性自身免疫性类风湿性疾病 (SARD) 的患者中查间歇性肺病 (ILD). 升高的CA 15-3水平准确地识别了SARD-ILD患者,有助于早期检测.
科学领域:
- 类风湿病学 类风湿病学
- 肺部病理学 肺部病理学
- 生物标志物发现发现
背景情况:
- 系统性自身免疫性风湿性疾病 (SARD) 中的间歇性肺病 (ILD) 呈现出可变的结果和显著的死亡率.
- 早期发现SARD-ILD对于改善患者管理至关重要.
- 像KL-6和CA 15-3这样的血清生物标志物与ILD的发病有关.
研究的目的:
- 评估血清碳水化合物抗原15-3 (CA 15-3) 的诊断准确性,作为新诊断的SARD患者ILD的查生物标志物.
- 评估CA 15-3水平与其他ILD指标和临床参数的相关性.
主要方法:
- 这是一项单一中心的横截面研究,涉及新诊断的SARD患者.
- 患者接受了高分辨率计算机断层扫描 (HRCT) 进行ILD评估.
- 测量和分析了CA 15-3,KL-6和乳酸脱酶 (LDH) 的血清水平.
主要成果:
- 在ILD患者中,血清CA 15-3和LDH水平显著更高 (P<0.001).
- 升高的CA 15-3与KL-6和LDH正相关,与FVC和DLCO相反.
- CA 15-3显示出高诊断准确度 (AUC=0.807),截止值为24U/mL,具有95.7%的特异性和71.1%的灵敏度.
结论:
- 血清CA 15-3是一种有前途的生物标志物,用于查SARD患者的ILD.
- 它能够预测积极的HRCT发现的能力表明,在常规临床实践中用于早期SARD-ILD检测的实用性.
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