在瘤治疗中与免疫检查点抑制剂相关的B型肝炎病毒重新激活风险:一项回顾性研究
Yue Yin1, Bao Jiang Liu2, Yan Hua Zhang1
1Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Pharmacy, Peking University Cancer Hospital & Institute, Beijing 100142, China.
Japanese journal of clinical oncology
|August 24, 2024
概括
乙型肝炎病毒 (HBV) 再激活是免疫检查点抑制剂 (ICI) 治疗癌症患者的风险. 抗病毒预防可显著降低这种风险,强调需要在ICI治疗期间对HBV监测和预防措施.
科学领域:
- 在瘤学瘤学.
- 肝病学 肝病学是一种肝病学.
- 免疫学 免疫学 免疫学
背景情况:
- 乙型肝炎病毒 (HBV) 再激活是化疗的已知风险.
- 癌症患者使用免疫检查点抑制剂 (ICI) 的HBV重新激活的风险尚未确立.
- 这项研究调查了接受ICI治疗的癌症患者的HBV再激活发生率和风险因素.
研究的目的:
- 为了确定在接受ICI治疗的癌症患者中HBV重新激活的发生率.
- 为了确定与该患者群体中HBV重新激活相关的风险因素.
主要方法:
- 癌症患者的回顾性研究对乙型肝炎表面抗原 (HBsAg) 呈阳性.
- 主要终点:HBV重新激活的发生率.
- 二级终点:在ICI治疗期间发生肝脏不良事件.
主要成果:
- 在162名患者中,4.3%的患者发生了HBV复激活,平均发病时间为13周.
- 没有抗病毒预防的患者的活性化率为8.1%,而预防的患者为1.1%.
- 缺乏抗病毒治疗是HBV重新激活的重要危险因素.
结论:
- 在ICI治疗的癌症患者面临着HBV重新激活的显著风险.
- 抗病毒预防和定期监测HBVDNA是必要的预防策略.
- 对接受ICI治疗的患者来说,监测HBV状态至关重要,以减轻重新激活风险.
相关概念视频
Tumor Immunotherapy
493
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
493
Pulmonary Tuberculosis I
227
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
227


