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Updated: Jun 15, 2025

In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Naïve CD4+ T Cells Using a TGF-β-containing Protocol
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In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Naïve CD4+ T Cells Using a TGF-β-containing Protocol

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人类胸腺衍生效应因子Tregs的免疫抑制依赖于葡萄糖/乳酸燃料脂肪酸合成

Sander de Kivit1, Mark Mensink1, Sarantos Kostidis2

  • 1Department of Immunology, Leiden University Medical Center, 2300 RC Leiden, the Netherlands; Oncode Institute, Leiden University Medical Center, 2300 RC Leiden, the Netherlands.

Cell reports
|August 24, 2024
PubMed
概括

调控性T细胞 (Tregs) 使用脂肪酸合成进行增殖和功能,与传统的T细胞不同. 这种脂质代谢对Treg介导的抑制至关重要,突出了它们在炎症组织中的适应性.

关键词:
(监管) 的T细胞.CP: 免疫学 免疫学CP:新陈代谢过程中的新陈代谢整体刺激的方法是 costimulation脂肪酸 脂肪酸 脂肪酸 脂肪酸葡萄糖溶解是什么免疫抑制 免疫抑制同位素探测器的追踪.乳酸乳酸是一种乳酸.脂质组的类型是什么质谱测量质谱测量质谱测量质量测量质谱测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量代谢 代谢 代谢 代谢

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相关概念视频

T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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