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通过电化学传感器检测三甲基胺N-氧化物,该传感器基于用分子印制聚烯-基 (III) 硫化物纳米片修改的丝网打印电极

Shreeti Chakravorty¹, Archana¹, Gbvs Lakshmi¹

¹Nano-bio Laboratory, Special Center for Nanoscience, Jawaharlal Nehru University, New Delhi 110067, India.

Colloids and surfaces. B, Biointerfaces

|August 24, 2024

概括

使用聚烯和硫化纳米片的新型电化学传感器检测到三甲基胺N氧化物 (TMAO). 这一进步有助于早期诊断疾病,使得在人类样本中快速和选择性地检测TMAO.

科学领域:

电化学电化学电化学
材料科学材料科学材料科学
生物医学传感传感器

背景情况:

三甲基胺N氧化物 (TMAO) 是一种肠道代谢物,与各种疾病有关,包括癌症和心血管疾病.
改变的TMAO水平需要可靠和快速的检测方法来了解疾病的发病和治疗.
现有的检测技术可能缺乏早期疾病诊断所需的速度,灵敏度或选择性.

研究的目的:

制造一种新的电化学传感器,用于对三甲基胺N氧化物 (TMAO) 的敏感和选择性检测.
开发一种生物流体中TMAO的快速诊断工具,以帮助早期识别疾病.
探索聚 (Ppy) @ (III) 硫化物 (Mo2S3) 纳米板复合分子印记聚合物 (MIP) 的潜力,以提高传感能力.

主要方法:

通过化学氧化聚合和使用水热技术的Mo2S3纳米板合成聚烯 (Ppy).
一个Ppy@Mo2S3-MIP复合电化学传感器的制造.
使用XRD,拉曼,FTIR,SEM和TEM进行纳米复合材料的表征;电化学性能评估.

主要成果:

该Ppy@Mo2S3-MIP传感器显示TMAO的线性检测范围为30210μM.
实现了高灵敏度为1.21 μA μM-1 cm-2和低检测极限为1.4 μM.
与Ppy-MIP相比,传感器对TMAO表现出更强的稳定性和选择性,并显示了在人类尿液中检测TMAO的潜力.

结论:

开发的Ppy@Mo2S3-MIP电化学传感器为快速和选择性TMAO检测提供了一个有前途的平台.
这项技术可以为早期诊断和了解TMAO相关疾病做出重大贡献.
该传感器在尿液等人体样本中的应用性突显了其在临床诊断方面的潜力.

关键词:

电化学传感器是一种电化学传感器.肠道微生物群衍生代谢物的代谢物有分子印记的聚合物.这就是TMAOO.电压测量是一种电压测量.

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