戒烟与目前吸烟对骨折风险的影响:曼尼托巴BMD注册表
Fatima Zarzour1, William D Leslie1
1Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
概括
吸烟会增加骨折的风险,即使在戒烟后. 最近的前吸烟者面临的骨折风险和现在的吸烟者一样高,这凸显了关于戒烟的进一步研究的需要.
科学领域:
- 骨健康和流行病学
- 老年医学 老年医学
- 公共卫生 公共卫生
背景情况:
- 目前的烟草吸烟是已知的骨折风险因素,已纳入FRAXTM计算器.
- 以前吸烟对骨折风险的影响尚不清楚.
- 了解吸烟对骨健康的长期影响对于预防策略至关重要.
研究的目的:
- 为了比较当前吸烟者,最近的前吸烟者和从未吸烟者之间的事件骨折风险.
- 调查戒烟是否能在短期内减轻骨折风险.
- 为精炼中断风险评估工具提供数据.
主要方法:
- 分析了来自加拿大马尼托巴的DXA注册表的18,115名40岁以上的个人队列.
- 参与者根据两次访问的吸烟状况被分为当前吸烟者,非吸烟者和前吸烟者.
- 通过医疗保健数据链接确定了事件骨折,并使用Cox比例危险模型分析了结果.
主要成果:
- 与非吸烟者相比,目前吸烟者患任何事件骨折的风险显著更高 (调整HR 1.22).
- 前吸烟者也表现出发生骨折的风险显著增加 (调整HR1.42),与目前吸烟者相似.
- 对于严重的骨质疏松和关节骨折,观察到类似的趋势,前吸烟者显示的风险估计接近目前吸烟者的风险估计.
结论:
- 最近戒烟与持续增加的短期骨折风险有关,与目前吸烟者的风险相当.
- 这些发现表明,戒烟对骨折风险的益处可能不会立即出现.
- 需要进一步的研究来确定戒烟后骨折风险降低的精确时间表.
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