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Updated: Jun 15, 2025

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通过与O-GlcNAc转移酶相互作用,SMAD4促进了COPD呼吸道改造中的EMT,这种改造是由香烟烟雾引起的

Ziteng Wang1, Yu Ding1, Pei Wang1

  • 1Department of Respiratory and Critical Care Medicine, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, Jiangsu 214023, PR China.

Ecotoxicology and environmental safety
|August 24, 2024
PubMed
概括

暴露于香烟烟雾会增加SMAD4和O-GlcNAcylation,从而推动COPD的气道重塑. 抑制O-GlcNAcylation减少了这一过程,揭示了COPD的新治疗点.

关键词:
气道改造 气道改造 气道改造慢性慢性肺炎是一种慢性慢性肺炎,COPD是一种慢性肺炎.香烟烟雾的烟雾是什么意思皮质 - 介质细胞过渡 (EMT)在O-GlcNAc转移酶.在SMAD4中,我们可以看到SMAD4.

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