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Updated: Jun 15, 2025

Monitoring Neuronal Survival via Longitudinal Fluorescence Microscopy
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在TDP-43的单一乙化模拟突变中核定位信号干扰了importin α1/β信号传输

Ying-Hui Ko1, Ravi K Lokareddy1, Steven G Doll2

  • 1Dept. of Biochemistry and Molecular Genetics, The University of Alabama at Birmingham, 1825 University Blvd, Birmingham, AL 35294, USA.

Journal of molecular biology
|August 24, 2024
PubMed
概括

在43kDa的TAR-DNA结合蛋白 (TDP-43) 中模仿乙化的一种特定突变导致其错位化和聚合,这是肌缩侧面硬化症 (ALS) 的关键特征. 这一发现揭示了零星的ALS分子原因.

关键词:
这就是ALS.在TDP-43中使用.进口中的α1α1进口中的β.核定位信号是一个核定位信号.

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