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纳米颗粒通过Nrf2通路激活减轻微塑料诱导的血管内皮损伤

Linhua Deng¹, Mengjun Li¹, Zhongjing Jiang¹

¹Department of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.

The Science of the total environment

|August 24, 2024

概括

微塑料 (MP) 和纳米颗粒 (CoNP) 伤害血管细胞. 它们的联合存在可以通过改变核因子红色素2相关因子2 (Nrf2) 信号来减少不良影响.

科学领域:

环境科学环境科学
毒理学毒理学毒理学
材料科学材料科学材料科学

背景情况:

塑料和合金被广泛使用,导致环境的微塑料 (MP) 和纳米粒子 (Co NP) 污染.
没有充分了解MP和CoNP对血管系统的影响.

研究的目的:

调查国会议员与国会议员之间的互动.
阐明它们对血管内皮细胞的影响,并确定潜在的机制.

主要方法:

扫描电子显微镜 (SEM) 用于粒子相互作用分析.
用血管内皮细胞进行体外实验.
斑马鱼研究用于体内验证.
分析反应性氧物种 (ROS) 和核因素红色素2相关因子2 (Nrf2) 信号通路.

主要成果:

议员和CoNP可以吸收和聚合.
无论是MP还是CoNP,都会单独损害血管内皮细胞的功能,并增加ROS的产生.
与单个暴露相比,对MP和CoNP的联合暴露导致了减弱的不良影响.
这两种粒子类型都诱导了异常的Nrf2信号,在组合中观察到的激活较弱.

结论:

MPs和Co NPs相互作用并影响血管内皮细胞.
联合暴露可能会减轻与单个暴露观察到的一些有毒效应.
Nrf2通路与对这些污染物的反应有关.

关键词:

心血管损伤是因为心血管损伤.纳米粒子是的纳米粒子.微塑料是一种微塑料.Nrf2 没有任何问题.这就是ROSOS ROS.

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