怀孕期间暴露与儿童喘发展的关联:日本环境与儿童研究
Shohei Kuraoka1, Masako Oda2, Takashi Ohba3
1The South Kyushu Okinawa Unit Center, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan; Department of Pediatrics, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan; Division of Nephrology, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
Environmental pollution (Barking, Essex : 1987)
|August 24, 2024
概括
产前接触某些,如布틸帕拉本,可能会增加儿童的喘风险. 怀孕期间对4-nonylphenol的低暴露似乎也是儿童喘发展的危险因素.
科学领域:
- 环境健康 环境健康
- 儿科过敏 儿科过敏
- 毒理学 毒理学 毒理学
背景情况:
- 消费产品中的基是广泛存在的环境污染物.
- 一些,如诺尼尔,是已知的内分泌干扰剂.
- 产前暴露与儿童喘之间的联系尚不清楚.
研究的目的:
- 调查孕早期母亲尿中醇度与儿童喘发育之间的关联.
- 分析与喘风险相关的特定,包括帕拉和非.
主要方法:
- 利用了来自日本环境和儿童研究 (JECS) 的数据,这是一个大型全国性的出生队列.
- 测量了3513名孕妇在怀孕第一季度的24种尿.
- 使用后勤回归来评估喘发病概率比率与醇暴露水平相关.
主要成果:
- 甲暴露显示了儿童喘发病的几率比率 (1.54) 的增加.
- 在男性儿童中,母体检测4-nonylphenol与更高的喘几率比率 (2.09) 有关.
- 观察到与4-nonylphenol暴露相关的喘风险的潜在性别差异.
结论:
- 在怀孕期间高含量布틸帕拉本和低含量4-诺尼尔暴露是儿童喘的潜在危险因素.
- 这些发现为推产前暴露的建议提供了基础.
- 需要进一步的研究来阐明机制,并为公共卫生指导方针提供信息.
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