一个基于纳米胡须的单维细菌纤维素二元药物输送系统用于癌症治疗
Xiaoli Liu1, Xiaofang Qian1, Zirui Yu1
1Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Department of Pharmacy, Nanjing University of Chinese Medicine, 138 Xianlin Rd, Nanjing 210023, China.
International journal of biological macromolecules
|August 24, 2024
概括
这项研究引入了一种基于细菌纤维素纳米胡须的新型化疗药物输送系统,有效地装载多克索鲁比辛和白醇. 这个系统显示了高的药物加载和释放,而白醇保护正常细胞,并最大限度地减少副作用.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 癌症治疗方法 癌症治疗方法
背景情况:
- 设计具有高药含量和最小副作用的化疗药物输送系统仍然是一个重大挑战.
- 现有的系统往往难以平衡有效性与患者安全,需要创新的方法.
研究的目的:
- 开发一种新的一维二元药物输送系统,用于增强癌症治疗.
- 提高药物加载和释放效率,同时减轻化疗的不良影响.
主要方法:
- 使用带有多多巴胺 (PDA) 封装的细菌纤维素纳米胡须 (BCW) 装载着多克索鲁比 (DOX) 和复星 (RES) 的二元药物输送系统的构建.
- 评估封装和药物加载效率,在酸性介质中的体外药物释放概况,以及通过内细胞分裂 (endocytosis) 的细胞吸收.
- 通过抗氧化酶活性和反应性氧物种清除,评估复星对正常细胞的抗癌作用和保护作用.
主要成果:
- 对DOX (81.53%) 和RES (70.32%) 实现了高封装效率,以及高药物加载效率 (DOX: 51.54%,RES: 36.93%).
- 在96小时内在酸性介质中显著的累积药物释放:89.27%的DOX和80.05%的RES.
- 经证实通过内细胞突变有效地进入瘤细胞,显著的抗癌作用,以及通过高调节抗氧化酶和清除活性氧物种来保护正常细胞的RES介导保护.
结论:
- 开发的单维BCW/DOX + RES/PDA系统为癌症治疗提供了一个有前途的策略.
- 这种二元药物输送系统实现了高药物负载和受控释放,而RES提供了对副作用的保护作用.
- 该系统展示了有效的抗癌疗法的潜力,并降低了毒性.
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