为制备具有抗紫外线,光转换和抗菌性质的多乳酸复合材料的新策略
Chengkai Liu1, Dongmei Wang2, Yanbo Li3
1Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China; College of Chemical and Environmental Engineering, Shandong University of Science and Technology, Qingdao 266510, China.
International journal of biological macromolecules
|August 24, 2024
概括
这项研究开发了一种新型的聚乳酸 (PLA) 复合物与稀土复合物,Eu(IAA) 2(phen) 2 (EuIP). 由此产生的PLA/EuIP材料表现出紫外线光转化,增强的抗紫外线性能和抗菌性能,使其成为一种多功能生物材料.
科学领域:
- 材料科学 材料科学 材料科学
- 聚合物化学 聚合物化学
- 纳米技术 纳米技术
背景情况:
- 聚乳酸 (PLA) 是一种可生物降解的聚合物,在抗紫外线和机械稳定性方面存在局限.
- 稀土复合物具有独特的光物理特性和材料增强的潜力.
- 开发多功能复合材料对于先进的材料应用至关重要.
研究的目的:
- 为了合成一种新的稀土复合物,Eu(IAA) 2 ((phen) 2 (EuIP).
- 通过化混合制造多功能多乳酸 (PLA) /EuIP复合物.
- 为了评估复合材料的光转化,紫外线抵抗,抗菌,生物相容性和生物降解性质.
主要方法:
- 以溶液为基础的Eu(IAA) 2 (EuIP) 2的合成.
- 在190°C时将EuIP与PLA混合.
- 光物理性质的表征 (光转换,UV-Vis透射率).
- 评估紫外线辐射稳定性 (分子量,机械性能).
- 对大肠杆菌和黄金杆菌的抗菌活性评估.
- 用4T1细胞进行体外细胞培养研究.
- 酶降解试验. 酶降解试验.
主要成果:
- 聚烯/EuIP复合材料证明了有效的紫外线转化为红光.
- 该PLA/1.0EuIP复合材料显示88%的可见光透射率和强烈的红色辐射.
- 在96小时的紫外线照射后,PLA/EuIP复合材料保持了分子量和机械性能,与干净的PLA不同.
- 观察到对大肠杆菌和金黄色杆菌有显著的抗菌活性.
- 复合材料支持4T1小鼠乳腺癌细胞的生长.
- 酶降解证实了PLA/EuIP复合材料的良好生物降解性.
结论:
- 开发的PLA/EuIP复合材料提供了出色的光转换和抗UV.
- 加入EuIP增强了PLA对抗紫外线降解的稳定性.
- 该复合材料表现出有希望的抗菌特性和生物相容性,可用于潜在的生物医学应用.
- 本研究提出了一种有效的策略,用于创建先进的多功能生物降解材料.
相关概念视频
Microbial Corrosion
Microbiologically Influenced Corrosion (MIC) is a significant form of material degradation caused by the metabolic activities of microorganisms. This phenomenon poses substantial challenges across various industries, including oil and gas, maritime, and water treatment sectors.MIC occurs when microorganisms, such as bacteria, archaea, and fungi, colonize metal surfaces, forming biofilms that alter the local electrochemical environment. These biofilms can lead to the production of corrosive...
Microbes in Food Production
Microbial fermentation is central to food biotechnology, enhancing flavor, texture, preservation, and stability. Fermentative microorganisms metabolize carbohydrates into organic acids, alcohols, and other metabolites that inhibit spoilage organisms and improve digestibility while contributing distinctive sensory qualities.In baking, amylases naturally present in flour hydrolyze starch into monosaccharides such as glucose, which Saccharomyces cerevisiae ferments anaerobically. Through...
Production of Organic Acids
Lactic acid, an important organic acid extensively applied in food, pharmaceutical, and biodegradable polymer industries, is primarily produced via microbial fermentation. This method is favored over chemical synthesis due to its environmental sustainability and capacity for enantiomerically pure product formation. Among various microbial processes, the fermentation of starch-based substrates stands out due to the abundance and renewability of raw materials like corn and potatoes.Hydrolysis of...
Production of Antibiotics
Penicillin, one of the earliest and most widely used antibiotics, is produced industrially by the filamentous fungus Penicillium chrysogenum. Large stirred-tank bioreactors ranging from tens to hundreds of thousands of liters maintain tightly controlled temperature, pH, and dissolved oxygen conditions to support fungal metabolism and maximize antibiotic yield. Penicillin is a secondary metabolite, synthesized primarily during the stationary growth phase, which requires a carefully managed...
Production of Pharmaceuticals
Industrial insulin production uses genetically engineered E. coli expressing a proinsulin gene controlled by a tryptophan promoter and containing a methionine linker for later cleavage. The cells also carry ampicillin resistance for selective growth. Seed cultures are stored at −80 °C and production begins by thawing a small amount to inoculate starter cultures, which are progressively scaled to a 50,000-L bioreactor. In the bioreactor, E. coli grow in nutrient-rich media under sterile, tightly...
Bioplastics
Bioplastics derived from microbial processes present a sustainable alternative to conventional petroleum-based plastics. Among these, polyhydroxyalkanoates (PHAs), particularly polyhydroxybutyrates (PHBs), have emerged as prominent candidates due to their biodegradability and biocompatibility. These polymers are synthesized by a variety of bacteria, such as Cupriavidus necator and Pseudomonas putida, which naturally accumulate PHAs as intracellular carbon and energy reserves, especially under...


