间歇性卡路里限制对非糖尿病患者的作用,这些患者患有与代谢功能障碍相关的肥胖性肝病
Han Ah Lee1, Hyeyoung Moon2, Yuri Kim2
1Department of Internal Medicine, College of Medicine, Chung-Ang University, Seoul, Republic of Korea.
概括
间歇性卡路里限制 (ICR) 显著降低了肝脏脂肪含量 (LFC),超过了在患有代谢功能障碍相关的脂肪性肝病的患者的标准护理饮食. 这种效应在肥胖个体中尤为明显.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢障碍 代谢障碍 代谢障碍
- 饮食干预 饮食干预
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个日益严重的健康问题.
- 准确评估肝脏脂肪含量 (LFC) 对疾病管理至关重要.
- 标准护理 (SOC) 饮食是目前MASLD管理的指导方针.
研究的目的:
- 为了比较12周间歇性卡路里限制 (ICR) 饮食与SOC饮食在减少MASLD患者的LFC中的有效性.
- 评估ICR对LFC的影响,特别是在患有或没有肥胖的患者中.
主要方法:
- 一项随机对照试验涉及72名MASLD患者,LFC (磁共振成像-质子密度脂肪分数) ≥8%.
- 患者被随机分配到ICR (5:2饮食) 或SOC (80%推摄入量) 在12周内.
- 主要结局:实现≥30%相对LFC减少的患者比例.
主要成果:
- 与SOC相比,更高比例的ICR患者实现了≥30%的LFC减少 (72.2%与44.4%,P=.033).
- 在肥胖患者中,ICR的益处更为显著 (61.1%对27.7%,P=.033).
- 在ICR组中,肥胖患者的相对体重减少更大 (-5.5%对-2.9%,P=.039).
结论:
- 在减少MASLD患者的LFC方面,ICR饮食比SOC更有效,特别是在肥胖患者中.
- 建议在更大,更多样化的群体中进行进一步的研究.
- 作为MASLD管理的有效饮食策略,ICR显示出前景.
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