肝炎E感染在中国的流行和发病率
Sailimai Man1, Jingzhu Fu2, Xiaochen Yang3
1Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China; Department of Evidence-based Medicine and Biostatistics, Meinian Institute of Health, Beijing, China; Meinian Public Health Institute, Peking University Health Science Center, Beijing, China; Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing, China.
概括
肝炎E病毒 (HEV) IgG在中国的患病率为18.02%,血清转化发生率为每100人/年1.79. 高龄和社会经济因素是HEV感染的关键风险.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 中国是肝炎E病毒 (HEV) 流行地区.
- 了解HEV的流行和发病率对于有效的公共卫生战略至关重要.
- 这项研究解决了对中国HEV的最新流行病学数据的需求.
研究的目的:
- 确定中国人口中抗HEVIgG抗体的流行率.
- 要计算HEV血清转换的发病率.
- 确定与中国的HEV血清转化相关的风险因素.
主要方法:
- 利用来自中国24个省份 (2017-2022) 的大型健康检查数据库.
- 针对抗HEVIgG患病率的横截面分析,根据2020年中国人口普查进行标准化.
- 对HEV血清转化发生率和Poisson回归用于风险因素识别的纵向分析.
主要成果:
- 包括85,238名参与者的流行率和11,154人的发病率.
- 总体而言,抗HEVIgG的流行率为18.02%.
- 在平均1.2年的随访期间,HEV血清转化发生率为每100人/年1.79. 独立的风险因素包括年龄≥60岁,低社会经济地位,沿海居住,高排水密度和高局部HEV IgG流行率.
结论:
- 该研究提供了关于中国HEV感染的关键流行病学数据.
- 这些发现突出了HEV血清转换的特定人口和地理风险因素.
- 结果可以为在中国和全球范围内针对肝炎E的有针对性的预防和控制政策提供信息.
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