在中国广州 (2008-2020年) 中,不断发展的分子HIV群体揭示了基因型特定的动态
Huanchang Yan1, Yefei Luo2, Hao Wu2
1School of Public Health and Management, Guangzhou University of Chinese Medicine, Guangzhou, China; Department of Medical Statistics, School of Public Health, Sun Yat-sen University, Guangzhou, China.
概括
在广州,分子HIV群集 (MHCs) 显示了基因型特定的传播动态. 集群率下降和稳定的网络结构表明,艾滋病毒控制方面取得了进展,但不断增长的集群需要有针对性的干预措施.
科学领域:
- 流行病学 流行病学
- 病毒学 病毒学
- 公共卫生 公共卫生
背景情况:
- 艾滋病毒分子集群 (MHCs) 对于理解传播动态至关重要.
- 基因型特定的传播适应性影响HIV流行病模式.
- 有效的艾滋病毒控制需要监测集群演变.
研究的目的:
- 在中国广州研究基因型特定的分子HIV群集动态.
- 评估随着时间的推移,集群率和网络结构的趋势.
- 为针对性的艾滋病毒预防和控制策略提供信息.
主要方法:
- 广州市8355名艾滋病毒感染者 (PWH) 的艾滋病毒聚序序的分析 (2008-2020).
- 基因型和分子网络构建以识别和分类MHC (新兴,增长,稳定).
- 用于评估集群率和比例趋势的joinpoint回归.
主要成果:
- CRF07_BC和CRF01_AE是最常见的HIV-1基因型;自2012年以来,组成稳定.
- 总体聚类率为43.3%,具有显著的基因型特定变异 (P < 0.001).
- 观察到到2020年底集群率的下降以及趋向于稳定的网络结构的趋势;由CRF55_01B,CRF07_BC和CRF59_01B主导的集群正在增长.
结论:
- 演变的MHC表现出基因型特定的动态,为艾滋病毒控制提供了洞察力.
- 集群率下降和网络稳定表明成功的公共卫生干预措施.
- 优先干预应针对生长集群,特别是那些由特定基因型主导的集群.
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