作为具有代谢和内分泌干扰影响的持久污染物的和多基物质
Lucas Gaillard1, Robert Barouki1, Etienne Blanc1
1Université Paris Cité - INSERM UMR 1124 T3S, 45 rue des Saints-Pères, 75006, Paris, France.
Trends in endocrinology and metabolism: TEM
|August 24, 2024
概括
和多基基物质 (PFAS) 是无处不在的环境污染物. 这篇评论详细介绍了它们对人类生育能力,甲状腺功能和新陈代谢的内分泌干扰作用,突出了重要的健康问题.
科学领域:
- 环境健康科学 环境健康科学
- 内分泌学 在内分泌学.
- 毒理学 毒理学 毒理学
背景情况:
- 和多基基物质 (PFAS) 是广泛使用的工业化学品,以其在环境和人体中的持久性而闻名.
- 人类接触PFAS几乎是不可避免的,因为它们的广泛存在和耐降解性.
- PFAS被认为是内分泌干扰化学物质,可能对人类健康产生不利影响.
研究的目的:
- 审查PFAS暴露对人类生育能力,甲状腺功能和代谢健康的内分泌干扰影响.
- 综合有关各种PFAS类别多样性毒理作用的当前知识.
- 为了强调由大量的PFAS分子及其多样化的生物效应产生的复杂性.
主要方法:
- 关于PFAS及其健康影响的最新科学研究的文献综述.
- 对研究PFASs内分泌干扰性质的研究进行分析.
- 综合了与PFAS暴露相关的生殖毒性,甲状腺功能障碍和代谢障碍数据.
主要成果:
- 暴露于PFAS与内分泌干扰有关,影响甲状腺功能,这可能会影响新生儿的认知发展.
- 证据表明,PFAS类之间有不同的生殖毒性,影响男性精子参数,与女性子宫内膜异位症相关.
- 代谢障碍,包括肥胖,2型糖尿病 (T2DM),失脂血症和肝毒性,与PFAS暴露有关,特别是在幼儿时期.
结论:
- PFAS对人类内分泌功能,生育能力和代谢健康构成重大威胁.
- 众多PFAS化合物的多样化化学结构和混合作用对风险评估和减轻构成了复杂的挑战.
- 进一步的研究至关重要,以了解全方位的PFAS毒性,并制定有效的策略,以尽量减少人类暴露和健康影响.
相关概念视频
01:36Types of Toxins
1.7K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
1.7K
01:20Types of Step-Growth Polymers: Polyesters
2.2K
The introduction of polyesters has brought major development to the textile industry. The wrinkle-free behavior of polyester blends has eliminated the need for starching and ironing clothes.
Polyesters are commonly prepared from terephthalic acid and ethylene glycol; the crude product is known as poly(ethylene terephthalate) or PET. However, polyesters are synthesized industrially by transesterification of dimethyl terephthalate with ethylene glycol at 150 °C. The two reactants and the...
Polyesters are commonly prepared from terephthalic acid and ethylene glycol; the crude product is known as poly(ethylene terephthalate) or PET. However, polyesters are synthesized industrially by transesterification of dimethyl terephthalate with ethylene glycol at 150 °C. The two reactants and the...
2.2K
01:26Toxic Reactions: Overview
958
When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
958
01:00Characteristics and Nomenclature of Homopolymers
3.0K
Polymers that are made up of identical monomer units are called homopolymers. Only one repeating unit is involved in the construction of the homopolymer structure. For example, as depicted in Figure 1, polypropylene is a homopolymer constituted of propylene monomers. Here, the only repeating unit in the polymer chain is propylene.
3.0K