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Updated: Jun 15, 2025

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自组装的超结构减轻了冷-EM中的空气-水接口效应.

Liming Zheng1, Jie Xu2,3, Weihua Wang4

  • 1Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China.

Nature communications
|August 24, 2024
PubMed
概括

使用石墨烯表面活性剂自组装单层 (GSAM) 的新方法克服了冷电子显微镜 (cryo-EM) 中的空气-水接口挑战. 这种技术改善了蛋白质结构的确定,使小和大蛋白质复合物的高分辨率分析成为可能.

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相关概念视频

Cryo-electron Microscopy01:28

Cryo-electron Microscopy

Conventional electron microscopy (EM) involves dehydration, fixation, and staining of biological samples, which distorts the native state of biological molecules and results in several artifacts. Also, the high-energy electron beam damages the sample and makes it difficult to obtain high-resolution images. These issues can be addressed using cryo-EM, which uses frozen samples and gentler electron beams. The technique was developed by Jacques Dubochet, Joachim Frank, and Richard Henderson, for...
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