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Updated: Jun 15, 2025

Author Spotlight: Investigating the Motion Dynamics of the Eukaryotic Replisome Components at the Single-Molecule Level
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Author Spotlight: Investigating the Motion Dynamics of the Eukaryotic Replisome Components at the Single-Molecule Level

Published on: July 26, 2024

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MCM2-7负载依赖的ORC释放确保了全基因组原产地许可证.

L Maximilian Reuter1,2, Sanjay P Khadayate3, Audrey Mossler4

  • 1DNA Replication Group, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, United Kingdom. m.reuter@imb-mainz.de.

Nature communications
|August 24, 2024
PubMed
概括

原始识别复合体 (ORC) 和在DNA复制原点的MCM2-7酶负载对于基因组复制至关重要. 这项研究揭示了ORC结合点封闭和DNA元素间距如何确保精确的酶加载,防止DNA复制过程中的错误.

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