在牙科随机对照试验中评估透明度实践
Mayara Colpo Prado1, Lara Dotto2, Bernardo Agostini1
1Graduate Program in Dentistry, ATITUS Educação, Passo Fundo, RS, Brazil.
BMC medical research methodology
|August 24, 2024
概括
牙科随机对照试验 (RCT) 的透明度较低,特别是数据共享. 协议注册有所不同,而利益冲突和资金披露是常见的. 促进透明度对于基于证据的牙科至关重要.
科学领域:
- 牙科研究 牙科研究
- 临床试验 临床试验
- 超级研究 (Meta-Research) 是一种研究方法.
背景情况:
- 透明度对于科学研究的完整性至关重要.
- 随机对照试验 (RCT) 是基于证据的牙科的基础.
- 评估目前牙科RCT中的透明度实践是必不可少的.
研究的目的:
- 评估已发表的牙科随机对照试验 (RCT) 中透明度实践的程度.
- 确定跨不同牙科专业和地理区域的关键透明度元素的报告模式.
主要方法:
- 一项分析2016年至2021年间英语出版的牙科RCT的元研究研究.
- 在PubMed数据库进行系统搜索.
- 重复选和数据提取,重点关注协议注册,数据/代码共享,利益冲突和资金披露.
主要成果:
- 在844个RCT中,只有12.86%报告了数据/代码共享,而50.36%报告了协议注册.
- 广泛报道了利益冲突 (83.41%) 和资金 (71.68%) 的声明.
- 数据共享和协议注册在全球和各专业之间显示出显著的变化,与利益冲突和资金冲突不同.
结论:
- 遵守透明的科学标准,包括协议注册和数据/代码共享,需要在牙科研究中显著改进.
- 促进对透明度要素的一致报告对于推进基于证据的牙科至关重要.
- 研究人员和机构的积极参与是培养透明度文化的必要条件.
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