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相关概念视频

Blinding01:11

Blinding

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Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.
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Blind Procedures02:07

Blind Procedures

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Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which...
10.6K
Clinical Trials01:16

Clinical Trials

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Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
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Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

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Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
124
Ethics in Research01:56

Ethics in Research

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Today, scientists agree that good research is ethical in nature and is guided by a basic respect for human dignity and safety. However, this has not always been the case. Modern researchers must demonstrate that the research they perform is ethically sound.
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Randomized Experiments01:13

Randomized Experiments

6.8K
The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
Simple...
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相关实验视频

Updated: Jun 15, 2025

Accuracy in Dental Medicine, A New Way to Measure Trueness and Precision
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在牙科随机对照试验中评估透明度实践.

Mayara Colpo Prado1, Lara Dotto2, Bernardo Agostini1

  • 1Graduate Program in Dentistry, ATITUS Educação, Passo Fundo, RS, Brazil.

BMC medical research methodology
|August 24, 2024
PubMed
概括

牙科随机对照试验 (RCT) 的透明度较低,特别是数据共享. 协议注册有所不同,而利益冲突和资金披露是常见的. 促进透明度对于基于证据的牙科至关重要.

关键词:
牙科 牙科是指牙科的专业.超级研究的研究.随机对照试验是随机对照试验.研究报告研究报告

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科学领域:

  • 牙科研究 牙科研究
  • 临床试验 临床试验
  • 超级研究 (Meta-Research) 是一种研究方法.

背景情况:

  • 透明度对于科学研究的完整性至关重要.
  • 随机对照试验 (RCT) 是基于证据的牙科的基础.
  • 评估目前牙科RCT中的透明度实践是必不可少的.

研究的目的:

  • 评估已发表的牙科随机对照试验 (RCT) 中透明度实践的程度.
  • 确定跨不同牙科专业和地理区域的关键透明度元素的报告模式.

主要方法:

  • 一项分析2016年至2021年间英语出版的牙科RCT的元研究研究.
  • 在PubMed数据库进行系统搜索.
  • 重复选和数据提取,重点关注协议注册,数据/代码共享,利益冲突和资金披露.

主要成果:

  • 在844个RCT中,只有12.86%报告了数据/代码共享,而50.36%报告了协议注册.
  • 广泛报道了利益冲突 (83.41%) 和资金 (71.68%) 的声明.
  • 数据共享和协议注册在全球和各专业之间显示出显著的变化,与利益冲突和资金冲突不同.

结论:

  • 遵守透明的科学标准,包括协议注册和数据/代码共享,需要在牙科研究中显著改进.
  • 促进对透明度要素的一致报告对于推进基于证据的牙科至关重要.
  • 研究人员和机构的积极参与是培养透明度文化的必要条件.