在接受化疗的肺癌患者中,抑郁的发展轨迹和预测因素:生长混合物模型
Yuanyuan Luo1, Dongmei Mao1, Le Zhang1
1School of Nursing, Southern Medical University, No.1023, South Shatai Road, Baiyun District, Guangzhou, 510515, Guangdong, China.
BMC psychiatry
|August 24, 2024
概括
在接受化疗的肺癌患者中确定了抑郁的轨迹. 诸如酒精史和失业率等因素预测了更高的抑郁症,强调了有针对性的症状管理的必要性.
科学领域:
- 在瘤学瘤学.
- 精神病学是一个精神病学.
- 症状科学 症状科学
背景情况:
- 抑郁症在化疗期间在肺癌患者中很常见.
- 疲劳-疼痛-失眠症状集群可能会影响抑郁症水平.
- 了解抑郁的轨迹可以为有针对性的干预提供信息.
研究的目的:
- 确定抑郁症和疲劳-疼痛-失眠症状集群轨迹.
- 探索预测肺癌患者不同抑郁轨迹的因素.
主要方法:
- 在接受化疗的187名肺癌患者的长度研究.
- 在多个时间点评估抑郁症 (PHQ-9),疼痛 (BPI),疲劳 (BFI) 和失眠 (AIS).
- 使用增长混合模型 (GMM) 和潜在类分析 (LCA) 进行轨迹识别;用于预测因素的二进制后勤回归.
主要成果:
- 确定了两个抑郁的轨迹:高下降 (40.64%) 和低增长 (59.36%).
- 近一半 (48.66%) 的患者有高症状集群轨迹.
- 酒精消费史,失业率和较低收入预测了抑郁症的高下降轨迹.
结论:
- 肺癌化疗患者表现出明显的抑郁和症状集群轨迹.
- 症状管理对于这些患者的抑郁症至关重要.
- 那些有酒精使用史,失业或低收入的人需要专注关注.
相关概念视频
Cancer Survival Analysis
334
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
334
Statistical Methods for Analyzing Epidemiological Data
336
Epidemiological data primarily involves information on specific populations' occurrence, distribution, and determinants of health and diseases. This data is crucial for understanding disease patterns and impacts, aiding public health decision-making and disease prevention strategies. The analysis of epidemiological data employs various statistical methods to interpret health-related data effectively. Here are some commonly used methods:
336
Comparing the Survival Analysis of Two or More Groups
162
Survival analysis is a cornerstone of medical research, used to evaluate the time until an event of interest occurs, such as death, disease recurrence, or recovery. Unlike standard statistical methods, survival analysis is particularly adept at handling censored data—instances where the event has not occurred for some participants by the end of the study or remains unobserved. To address these unique challenges, specialized techniques like the Kaplan-Meier estimator, log-rank test, and...
162
Kaplan-Meier Approach
115
The Kaplan-Meier estimator is a non-parametric method used to estimate the survival function from time-to-event data. In medical research, it is frequently employed to measure the proportion of patients surviving for a certain period after treatment. This estimator is fundamental in analyzing time-to-event data, making it indispensable in clinical trials, epidemiological studies, and reliability engineering. By estimating survival probabilities, researchers can evaluate treatment effectiveness,...
115


