临床Enterococcus faecalis分离体中抗菌素耐药性的全球状况:系统性审查和元分析
Lingbo Guan1, Masoumeh Beig2, Lina Wang1
1Department of Intensive Care Unit, Linping Campus, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 311100, Zhejiang, China.
Annals of clinical microbiology and antimicrobials
|August 24, 2024
概括
在全球范围内,Enterococcus faecalis的抗生素耐药性正在增加. 达普托米辛和tigecycline显示对这些耐药菌株的有效性,而欧洲和澳大利亚提供预防策略.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 菌 (Enterococcus faecalis) (E. faecalis) 是一种机会性病原体,在全球引起与医疗保健相关的重大感染.
- 在E. faecalis中抗生素耐药性的增加构成了日益增长的全球健康威胁.
研究的目的:
- 进行一项元分析,评估临床E. faecalis分离物中聚合的抗生素耐药性率.
- 评估耐药性趋势随着时间的推移,跨地理区域,并根据感染源.
主要方法:
- 在PubMed,Scopus和Web of Science数据库中的系统文献搜索.
- 使用R统计包进行的统计分析.
- 包括来自28个国家的74项研究.
主要成果:
- 随着时间的推移,对氨基醇,斯福米辛,伊米佩内姆,线索利德,米诺环素,诺弗洛克萨,普里斯-达尔夫普里斯和四环素的耐药性率呈现出越来越高的趋势.
- 在不同的国家中观察到对安培西林,氨基醇,红色素,胺素,青素,利芬素,提科普拉宁,四环素和胺素的耐药性率的显著变化.
结论:
- 抗药性E. faecalis菌株的全球流行率正在增加.
- 达普托米辛和tigecycline被确定为对E. faecalis感染的有效治疗选择.
- 来自欧洲和澳大利亚等耐药性较低的地区的预防策略可能对耐药性较高的地区有益.
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