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Updated: Jun 15, 2025

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在ASIC1 β11-12链接器中,氨酸替代物缓慢降低敏感度

Rutambhara Purohit1, Tyler Couch1, Matthew L Rook1

  • 1Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York.

Biophysical journal
|August 25, 2024
PubMed
概括

在酸感应离子通道 (ASIC) 中引入普罗林,通过改变链接体构造,显著减缓了脱敏. 一个单个修改的子单元足以使整个三元体ASIC通道变得不敏感.

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