相关实验视频
Updated: Jun 15, 2025

09:52
Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
Published on: March 16, 2018
9.4K
酸通过调节ATF3/DUSP1信号通路来缓解噪音引起的听力损失
Rui Liang1, Weilong Wang2, Wei Gao1
1Department of Otolaryngology Head and Neck Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
Ecotoxicology and environmental safety
|August 25, 2024
概括
酸 (Cal) 通过减少尾中的氧化应激和亡来防止噪声引起的听力损失 (NIHL). 这项研究揭示了Cal Cal.
科学领域:
- 耳鼻神经科学 耳鼻神经科学
- 分子生物学分子生物学
- 药理学 药理学 是一个学科.
背景情况:
- 维生素D的活性形式 (Cal) 具有抗氧化和抗炎性质.
- 噪音引起的听力损失 (NIHL) 是与尾中的氧化应激相关的重大健康问题.
- 调查Cal在NIHL中的作用可以阐明噪音诱导的耳损伤的机制.
研究的目的:
- 在小鼠模型中研究酸 (Cal) 对噪声引起的听力损失 (NIHL) 的保护作用.
- 探索Cal作用的潜在机制,重点关注尾中的氧化应激和亡.
- 为了确定Cal是否在响应噪声暴露时调节ATF3/DUSP1信号通路.
主要方法:
- 在体内研究中,使用C57BL/6J小鼠暴露于噪音和 (Cal) 预处理.
- 听觉脑干反应 (ABR) 和耳外毛细胞损失评估用于听觉功能评估.
- 在体外实验中,使用耳扩展剂和HEI-OC1细胞,用三甲基氧化物 (TBHP) 诱导氧化应激,然后进行基因表达和蛋白质分析.
主要成果:
- 酸 (Cal) 预处理显著减轻噪声引起的听力损失 (NIHL),并保护了体内外部毛细胞.
- 在体外,Cal减少了TBHP诱导的耳神经纤维和螺旋质神经元的损伤,抑制了氧化应激标志物和亡.
- 发现cal调节ATF3/DUSP1信号通路,ATF3被确定为DUSP1.1的潜在直接转录因子.
结论:
- 酸 (Cal) 显示出对噪音引起的听力损失 (NIHL) 的保护作用.
- 可以通过抑制噪音诱导的亡和中的氧化应激来减弱NIHL.
- 保护机制包括调节ATF3/DUSP1信号通路.
相关概念视频
Calmodulin-dependent Signaling
5.1K
Calmodulin (CaM) is a calcium-binding protein in eukaryotes that controls various calcium-regulated cellular processes. It has four calcium-binding sites that bind calcium to form the calcium-calmodulin ( Ca2+-CaM) complex. GPCR stimulation increases the calcium levels in the cells that bind to CaM and induces a conformational change.
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...
5.1K
Synthesis and Functions of Calcitonin
1.7K
Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
1.7K
Role Of Notch Signalling In Intestinal Stem Cell Renewal
2.1K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.1K
Hormones and Bone Tissue
2.6K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.6K
Antihypertensive Drugs: Angiotensin II Receptor Blockers
625
In the renin-angiotensin-aldosterone system, a hormone called angiotensin II plays a crucial role. It binds to the AT1 receptors in vascular smooth muscles coupled with Gq proteins. The activation of these receptors activates an enzyme called phospholipase C, which releases two molecules: inositol trisphosphate and diacylglycerol. These molecules cause a chain reaction that leads to the phosphorylation of myosin light chains and promotes interaction between actin and myosin, leading to smooth...
625
Allosteric Proteins-ATCase
5.7K
Binding sites linkages can regulate a protein's function. For example, enzyme activity is often regulated through a feedback mechanism where the end product of the biochemical process serves as an inhibitor.
Aspartate transcarbamoylase (ATCase) is a cytosolic enzyme that catalyzes the condensation of L-aspartate and carbamoyl phosphate to N-carbamoyl-L-aspartate. This reaction is the first step in pyrimidine biosynthesis. UTP and CTP, the end products of the pyrimidine synthesis...
Aspartate transcarbamoylase (ATCase) is a cytosolic enzyme that catalyzes the condensation of L-aspartate and carbamoyl phosphate to N-carbamoyl-L-aspartate. This reaction is the first step in pyrimidine biosynthesis. UTP and CTP, the end products of the pyrimidine synthesis...
5.7K

