重复间隔的皮层配对关联性刺激促进了人体体运动电路中的附加性可塑性
Elana R Goldenkoff1, Joseph A Deluisi1, Taraz G Lee2
1School of Kinesiology, University of Michigan, Ann Arbor, USA.
概括
重复间隔的皮层配对关联刺激 (cPAS) 以剂量依赖的方式增加了运动皮层的刺激性. 多次cPAS会话累计增强了这种效果,表明了治疗应用的潜力.
科学领域:
- 神经科学是一个神经科学.
- 神经生理学 神经生理学
- 大脑刺激 大脑刺激
背景情况:
- 重复的横性磁性刺激 (TMS) 可以增强运动皮层的刺激能力.
- 之前的研究没有证明这种剂量依赖的效应在定义的皮质电路中.
研究的目的:
- 研究重复间隔的皮层配对关联刺激 (cPAS) 对运动皮层刺激性的影响.
- 为了确定多次cPAS会话是否会导致皮质刺激能力的累积,剂量依赖的增加.
主要方法:
- cPAS应用于主要运动皮层 (M1) 和后壁皮层 (PPC).
- 一个多剂量条件涉及三次cPAS会议间隔50分钟.
- 在cPAS之前和之后测量了运动唤起的潜能,以评估皮质刺激性.
主要成果:
- 与单剂量cPAS相比,多剂量cPAS显著增加了运动皮层刺激能力.
- 观察到一种累积的,剂量依赖的效应,每次相继的cPAS会话都会增强潜能.
- 这表明重复间隔cPAS对运动皮层刺激性的总和效应.
结论:
- 重复间隔的cPAS会话有效地增加了运动皮层刺激能力.
- 这种技术在恢复神经系统疾病 (如中风) 损害的功能方面表现有前途.
相关概念视频
Long-term Potentiation
2.7K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when...
Hebbian LTP
LTP can occur when...
2.7K
Somatosensory, Motor, and Association Cortex
449
The somatosensory cortex in the parietal lobes is crucial for interpreting sensory data such as touch, temperature, and proprioception. The somatosensory cortex, situated in the parietal lobes, plays a vital role in interpreting sensory information like touch, temperature, and proprioception—awareness of body position. This specialized brain region features an organized structure wherein neurons at the top primarily process sensations originating from the lower body. In contrast, those at...
449
Association Areas of the Cortex
5.2K
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
5.2K
Neuroplasticity
315
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
315


