导航人类肠道微生物群和乳腺癌之间的复杂关系:生理病理学,预后和治疗影响
Francesco Schettini1, Federica Gattazzo2, Sabrina Nucera3
1Translational Genomics and Targeted Therapies in Solid Tumors, August Pi I Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain; Department of Medical Oncology, Hospital Clinic of Barcelona, Barcelona, Spain.
Cancer treatment reviews
|August 25, 2024
概括
肠道微生物群影响乳腺癌的发展和进展. 了解这种联系可能会导致针对微生物失衡的新治疗策略,以获得更好的癌症治疗结果.
科学领域:
- 微生物学 微生物学
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 人体拥有数万亿种微生物,称为微生物群,其中很大一部分在肠道中.
- 宿主-微生物群关系的不平衡 - - 失生症 - - 越来越多地与包括乳腺癌在内的疾病有关.
- 乳腺癌仍然是女性癌症相关死亡的主要原因.
研究的目的:
- 提供人类微生物群的概述,重点关注肠道微生物群在乳腺癌中的作用.
- 讨论肠道微生物群与乳腺癌发育,进展和治疗反应之间的复杂相互作用.
- 探索潜在的治疗策略,包括肠道微生物群用于乳腺癌.
主要方法:
- 关于肠道微生物群和乳腺癌的当前科学文献的综述.
- 分析下一代测序技术用于微生物群的概况.
- 讨论该领域的既定和新兴术语.
主要成果:
- 肠道微生物群影响宿主免疫和新陈代谢 (雌激素,脂质,多),影响乳腺瘤生物学.
- 有证据表明,肠道微生物群失调和乳腺癌之间存在联系.
- 肠道微生物群也可能在乳腺癌中发挥作用,超出肠道微生物群的影响.
结论:
- 肠道微生物群是乳腺癌的一个重要因素,影响其发展和进展.
- 对肠道微生物群-乳腺癌轴的进一步研究可能会揭示新的治疗点.
- 了解肠道和内微生物群对于全面的乳腺癌管理至关重要.
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