客观睡眠时间和身体活动与心力衰竭风险的关联:一项前性队列研究
Xinru Chen1, Mingqing Zhou2, Jinyu Wang3
1The First School of Clinical Medicine, Southern Medical University, Guangzhou 510515, China; Center for Sleep and Circadian Medicine, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou 510370, China.
短暂的睡眠时间增加了心力衰竭 (HF) 的风险,但充足的体力活动 (PA),特别是中度至强度的PA (MVPA),可以降低这种风险. 长时间的睡眠时间与HF风险无关.
科学领域:
- 心脏病学 心脏病学
- 睡眠医学 睡眠医学
- 预防医学 预防医学
背景情况:
- 心力衰竭 (HF) 是一个重要的公共卫生问题.
- 了解睡眠和体力活动 (PA) 等可修改的风险因素对于预防至关重要.
- 之前的研究已经独立地探索了睡眠和PA,但它们对高频风险的综合影响需要进一步调查.
研究的目的:
- 检查加速度计衍生睡眠时间和不同强度的体力活动与发生心力衰竭 (HF) 的独立和联合关联.
主要方法:
- 利用了来自89,572名英国生物库参与者的数据 (平均年龄为62.2岁).
- 评估睡眠时间 (短,正常,长) 和PA (总,轻,中等至强烈[MVPA],强烈[VPA]) 使用加速度计超过7天.
- 在7年的随访期间,通过医院记录和死亡登记册识别了HF病例.
主要成果:
- 睡眠时间短 (<6小时/天) 与33%的高血压风险增加有关 (HR 1.33,95% CI: 1.11-1.59).
- 长时间睡眠时间 (>8小时/天) 与HF风险没有显著关联.
- 增加的PA,特别是满足MVPA或VPA建议,减轻了与睡眠短暂相关的HF风险.
- 与睡眠不足且不符合MVPA建议的参与者相比,睡眠正常且不符合MVPA建议的参与者,HF风险最高 (HR 1.78,95% CI: 1.42-2.25) .
结论:
- 短暂的睡眠时间是发生心力衰竭的独立风险因素.
- 足够的体力活动,特别是中度至强烈的PA,可以部分抵消与睡眠短暂相关的HF风险增加.
- 公共卫生战略应考虑睡眠时间和身体活动水平,以预防心力衰竭.
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