在接受化疗或化疗放射治疗的肺癌患者中使用CCTA评估冠状动脉和预测MACE
Yuhang Xie1, Hesong Shen1, Qian Xu2
1Department of Radiology, Chongqing University Cancer Hospital & Chongqing, Cancer Institute & Chongqing Cancer Hospital, Chongqing, China.
概括
冠状动脉计算机断层扫描 (CCTA) 可以检测与癌症治疗相关的冠状动脉损伤,并预测肺癌患者的主要不良心血管事件 (MACE). 像CT-FFR和FAI这样的关键参数在治疗前显示与MACE的关联.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
背景情况:
- 接受化疗 (CHT) 或化疗放射治疗 (CRT) 的肺癌患者可能会出现冠状动脉损伤.
- 冠状动脉计算机断层扫描 (CCTA) 检测这些障碍并预测主要不良心血管事件 (MACE) 的能力尚不清楚.
研究的目的:
- 在接受CHT或CRT的肺癌患者中使用CCTA参数评估冠状动脉.
- 在这个患者群体中探索CCTA参数和MACE之间的关联.
主要方法:
- 对697名肺癌患者的回顾性分析,这些患者在CHT/CRT之前或之后接受了CCTA.
- 使用倾向性得分匹配的患者组和对照组之间的CCTA参数 (FAI,CAC得分,CAD-RADS,狭窄,CT-FFR) 的比较.
- 使用考克斯回归和卡普兰-梅尔曲线,对CCTA参数与MACE的关联分析.
主要成果:
- 与治疗前对照组相比,肺癌患者的FAI,CAC得分,CAD-RADS,狭窄和CT-FFR较低.
- 在治疗后,CT-FFR下降,FAI增加,CRT组更明显的变化.
- 在治疗前较低的CT-FFR和较高的FAI与MACEs的增加有关.
结论:
- CCTA参数,特别是CT-FFR和FAI,可以识别与癌症治疗相关的冠状动脉损伤.
- 治疗前CT-FFR和FAI在接受CHT或CRT的肺癌患者中预测MACE.
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