维生素D3的应用及其在上腺皮质中的活性因素:一项功能性-组织学研究
Vladimir Ajdžanović1, Branka Šošić-Jurjević1, Jasmina Živanović1
1Department of Cytology, Institute for Biological Research "Siniša Stanković" - National Institute of Republic of Serbia, University of Belgrade, Despot Stefan Blvd., 142, Belgrade 11108, Serbia.
概括
在老年老鼠中补充维生素D3会增加皮质水平,这表明中央调节机制参与其中. 这项研究研究了维生素D.
科学领域:
- 内分泌学 在内分泌学.
- 历史学 历史学 历史学
- 分子生物学分子生物学
背景情况:
- 维生素D补充剂对老年人的健康参数产生积极影响.
- 气期与影响各种生理功能的荷尔蒙变化有关.
- 上腺皮质在激素生产中起着至关重要的作用,受到维生素D的影响.
研究的目的:
- 分析维生素D3对上腺皮质的功能性和组织学影响,以小鼠的色期模型为例.
- 研究维生素D3对维生素D受体 (VDR) 表达和相关酶活性的影响.
- 为了确定维生素D3对皮质激素产生的影响,在切除了的老鼠中.
主要方法:
- 中年Wistar大鼠被分为假操作,体切除 (Orx) 和体切除加维生素D3治疗 (Orx+vit. D) 团体. 组织.
- 维生素D3被用皮下注射了三个星期.
- 分析包括组织化学,免疫组织化学,立体学,超结构检查和生物化学分析.
主要成果:
- 兰花切除术降低了VDR,CYP 2R1和CYP 24的血管性和表达,同时增加了上皮层中的CYP 27B1.
- 维生素D3治疗在切除的老鼠增加了原蛋白,VDR,CYP 2R1和脂质滴径,同时降低了血管性,CYP 27B1和CYP 24.
- 血ACTH降低,而血清25-氧维生素D3和皮质在维生素D3的管理后增加.
结论:
- 在接受维生素D3治疗的形老鼠中,皮质的产量增加与25-基维生素D3的可用性或1,25-二基维生素D3在上腺组织中的降解没有直接联系.
- 这些发现表明,中央调节机制调解了观察到的皮质水平的增加.
- 维生素D3影响上腺皮质的结构和功能,在实验性断的背景下.
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