在基本战斗训练期间血清骨代谢标志物变化和骨微型结构变化之间的关联 - ARMI研究
Jennifer C Coulombe1, Brittany N Bozzini2, Katelyn I Guerriere2
1U.S. Army Research Institute of Environmental Medicine, Natick, MA, USA; Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center and Department of Orthopedic Surgery, Harvard Medical School, Boston, MA, USA.
基本战斗训练 (BCT) 增加了骨形成标志物PINP,特别是在前四周. 在接受BCT的士兵中,较高的PINP水平与改善的骨矿物质密度和结构相关.
科学领域:
- 整形外科 整形外科 整形外科
- 运动医学 运动医学
- 骨生物学 骨生物学 骨生物学
背景情况:
- 美国陆军的基本作战训练 (BCT) 在大多数士兵中提高了骨矿物质密度 (BMD) 和结构.
- 很少有研究探讨了血清骨生物标志物与BCT期间骨变化之间的关联.
研究的目的:
- 在BCT期间表征血清骨生物标记物的变化.
- 为了研究这些生物标志物变化和骨骨质量和骨结构的变化之间的关系.
主要方法:
- 在10周的BCT中,对235名美国陆军学员进行了前性观察研究.
- 每周收集血液样本以测量Procollagen类型1 N-终端 (PINP) 和C-终端端1型 (CTX) 每两周一次.
- 在基线和BCT后使用双能量X射线吸收度和高分辨率的外围定量计算断层扫描来评估腿骨骨质量,结构和微观架构.
主要成果:
- 在女性受训者中,PINP在BCT期间和之后显著增加,在第四周达到峰值 (45.4%).
- 男性受训者在第二周和第四周也显示PINP增加 (分别为21.9%和35.9%),在多个时间点观察到CTX下降.
- 从基线到第四周的PINP变化与BCT后的骨BMD,骨结构和微观架构的改善正相关.
结论:
- 骨形成标记物PINP在美国陆军BCT期间显著增加,最显著的增加发生在最初的四周.
- 在BCT期间PINP水平升高与骨矿物质密度增加和结构改善有关.
- 骨再吸收标记CTX的变化与这一队列的骨改善没有显著相关.
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